Zinc depletion efficiently inhibits pancreatic cancer cell growth by increasing the ratio of antiproliferative/proliferative genes.

@article{Donadelli2008ZincDE,
  title={Zinc depletion efficiently inhibits pancreatic cancer cell growth by increasing the ratio of antiproliferative/proliferative genes.},
  author={Massimo Donadelli and Elisa Dalla Pozza and Chiara Costanzo and Maria Teresa Scupoli and Aldo Scarpa and Marta Palmieri},
  journal={Journal of cellular biochemistry},
  year={2008},
  volume={104 1},
  pages={202-12}
}
We investigated the ability of the zinc chelator N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) to reduce pancreatic cancer cell viability. TPEN was much more efficient to inhibit pancreatic adenocarcinoma cell growth than a panel of anti-cancer drugs, including 5-fluorouracil, irinotecan, cisplatin, edelfosine, trichostatin A, mitomycin C, and gemcitabine, the gold standard chemotherapeutic agent for pancreatic cancer. Moreover, TPEN showed a dose- and time-dependent anti… CONTINUE READING
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