Zinc dependent binding of a liver nuclear factor to metal response element MRE-a of the mouse metallothionein-I gene and variant sequences.

@article{Searle1990ZincDB,
  title={Zinc dependent binding of a liver nuclear factor to metal response element MRE-a of the mouse metallothionein-I gene and variant sequences.},
  author={Peter F. Searle},
  journal={Nucleic acids research},
  year={1990},
  volume={18 16},
  pages={4683-90}
}
Metallothionein gene transcription is inducible by zinc and other heavy metals, and several metal response elements (MREs) have been mapped within about 200 bp upstream of the site of transcription initiation in several metallothionein genes. Comparison of a number of MREs defined a 15 bp consensus sequence containing a more highly conserved MRE core sequence TGCRCNCG. I have used the proximal MRE of the mouse metallothionein-I gene (MRE-a) in DNA fragment mobility shift assays to detect a… CONTINUE READING

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