Zinc delays clot lysis by attenuating plasminogen activation and plasmin-mediated fibrin degradation.

@article{Henderson2015ZincDC,
  title={Zinc delays clot lysis by attenuating plasminogen activation and plasmin-mediated fibrin degradation.},
  author={Sara J Henderson and Alan R. Stafford and Beverly A. Leslie and Paul Y Kim and Nima Vaezzadeh and Ran Ni and James C Fredenburgh and Jeffrey I Weitz},
  journal={Thrombosis and haemostasis},
  year={2015},
  volume={113 6},
  pages={1278-88}
}
Zinc circulates free in plasma at a concentration of 0.1-2 µM, but its levels increase locally when it is released from activated platelets. Although zinc influences many processes in haemostasis, its effect on fibrinolysis has not been thoroughly investigated. Using a fluorescent zinc-binding probe, we demonstrated that zinc binds tissue-type plasminogen activator (tPA) and plasmin with high affinity (Kd values of 0.2 µM), and surface plasmon resonance studies revealed that zinc binds fibrin… CONTINUE READING

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