Zinc deficiency induces membrane barrier damage and increases neutrophil transmigration in Caco-2 cells.

@article{Finamore2008ZincDI,
  title={Zinc deficiency induces membrane barrier damage and increases neutrophil transmigration in Caco-2 cells.},
  author={Alberto Finamore and Mara Massimi and Laura Conti Devirgiliis and Elena Mengheri},
  journal={The Journal of nutrition},
  year={2008},
  volume={138 9},
  pages={1664-70}
}
Zinc may contribute to the host defense by maintaining the membrane barrier. In this study, we questioned whether zinc deficiency affects the membrane function and junctional structure of intestinal epithelial cells, causing increased neutrophil migration. We used the Caco-2 cell line grown in control (C), zinc-deficient, or zinc-replete medium until differentiation. Zinc deprivation induced a decrease of transepithelial electrical resistance and alterations to tight and adherens junctions… CONTINUE READING
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