Zinc coordination geometry and ligand binding affinity: the structural and kinetic analysis of the second-shell serine 228 residue and the methionine 180 residue of the aminopeptidase from Vibrio proteolyticus.

@article{Ataie2008ZincCG,
  title={Zinc coordination geometry and ligand binding affinity: the structural and kinetic analysis of the second-shell serine 228 residue and the methionine 180 residue of the aminopeptidase from Vibrio proteolyticus.},
  author={N. Ataie and Quyen Q. Hoang and Megan P. D. Zahniser and Yupeng Tu and Amy Milne and G. Petsko and D. Ringe},
  journal={Biochemistry},
  year={2008},
  volume={47 29},
  pages={
          7673-83
        }
}
  • N. Ataie, Quyen Q. Hoang, +4 authors D. Ringe
  • Published 2008
  • Chemistry, Medicine
  • Biochemistry
  • The chemical properties of zinc make it an ideal metal to study the role of coordination strain in enzymatic rate enhancement. The zinc ion and the protein residues that are bound directly to the zinc ion represent a functional charge/dipole complex, and polarization of this complex, which translates to coordination distortion, may tune electrophilicity, and hence, reactivity. Conserved protein residues outside of the charge/dipole complex, such as second-shell residues, may play a role in… CONTINUE READING
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