Zinc as an inhibitor of myelin basic protein proteolytic breakdown in the central nervous system.

Abstract

It is known that central nervous system myelin contains proteolytic enzymes which degrade the myelin basic protein (MBP). We have found that zinc acetate is able to inhibit MBP cleavage at concentrations of 1 mM or higher. Furthermore, the Zn-inhibitable MBP-degrading activity was found to be water-soluble and able to recognize MBP also if this protein was… (More)

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@article{Liuzzi1991ZincAA, title={Zinc as an inhibitor of myelin basic protein proteolytic breakdown in the central nervous system.}, author={G. Liuzzi and A M Ventola and Tommaso Rizzo and Paul N Riccio and Ernesto Quagliariello}, journal={Acta neurologica}, year={1991}, volume={13 2}, pages={153-61} }