Zinc and insulin in pancreatic beta-cells

@article{Li2013ZincAI,
  title={Zinc and insulin in pancreatic beta-cells},
  author={Yang Li},
  journal={Endocrine},
  year={2013},
  volume={45},
  pages={178-189}
}
Zinc (Zn2+) is an essential element crucial for growth and development, and also plays a role in cell signaling for cellular processes like cell division and apoptosis. In the mammalian pancreas, Zn2+ is essential for the correct processing, storage, secretion, and action of insulin in beta (β)-cells. Insulin is stored inside secretory vesicles or granules, where two Zn2+ ions coordinate six insulin monomers to form the hexameric-structure on which maturated insulin crystals are based. The… CONTINUE READING
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