Zinc and human health: an update

  title={Zinc and human health: an update},
  author={Christos T. Chasapis and Ariadni C. Loutsidou and Chara A. Spiliopoulou and Maria E. Stefanidou},
  journal={Archives of Toxicology},
The importance of micronutrients in health and nutrition is undisputable, and among them, zinc is an essential element whose significance to health is increasingly appreciated and whose deficiency may play an important role in the appearance of diseases. Zinc is one of the most important trace elements in the organism, with three major biological roles, as catalyst, structural, and regulatory ion. Zinc-binding motifs are found in many proteins encoded by the human genome physiologically, and… 

Zinc Deficiency and Its Effect on the Brain: An Update

  • Kumar
  • Medicine, Biology
  • 2016
The role of Zn as anti-oxidant has a protective role against oxyradicals and its implications for neurodegenerative and other inflammatory diseases are reviewed.

The Role of Zinc and Copper in Gynecological Malignancies

The roles of zinc and copper and their mechanisms in tumor growth, metastasis potential, microenvironment remodeling, and drug resistance are reviewed, concentrating on their impact on gynecological malignancies.

Zinc and Selenium in Inflammatory Bowel Disease: Trace Elements with Key Roles?

This review has attempted to provide a comprehensive overview of the findings of these studies and to gather current knowledge about the association of these trace elements with the inflammatory process and inflammatory bowel disease.

Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms

This study presents selected issues regarding the current knowledge of anti-cancer mechanisms involving this element, including the influence of zinc on the immune system, transcription factors, cell differentiation and proliferation, DNA and RNA synthesis and repair, enzyme activation or inhibition, and the regulation of cellular signaling.

Aging, Immunity, and Neuroinflammation: The Modulatory Potential of Nutrition

This chapter discusses possible deleterious influences of immunosenescence and low-grade inflammation (inflammaging) on neurodegenerative processes in the normally aging brain, and considers the current understanding of the modulatory potential of nutrition that may mediate anti-inflammatory effects and thus positively affect immunity and the aging brain.

Role of zinc in diabetes mellitus , oxidative stress and other human healthy : a review article

A recent finding indicated that there is a direct relationship between low zinc levels, greater body fat content, and insulin resistance, and individuals who were classified as zinc deficient had poorer insulin sensitivity and greater glucose intolerance.

Zinc Transporters, Mechanisms of Action and Therapeutic Utility: Implications for Type 2 Diabetes Mellitus

It is suggested that zinc plays an unidentified role as a novel second messenger that augments insulin activity and raise a whole new area of research into the pathophysiology of insulin resistance and introduce a new class of drug target with utility for diabetes pharmacotherapy.

The Biomedical Role of Zinc in the Functioning of the Human Organism

The data presented in this article result from an overview of studies presented in literature published in the last five years concerning zinc transport mechanisms, the role of zinc in functioning of the human body, and also pathophysiological states caused by too low or excessive concentration of zincin an organism.

The science and practice of micronutrient supplementations in nutritional anemia: an evidence-based review.

The science of intestinal micronutrient absorption is reviewed, the clinical assessment of micronsutrient deficiencies in relation to anemia is discussed, and an effective treatment plan and monitoring strategies are suggested using an evidence-based approach.



Zinc: a multipurpose trace element

Physiological supplementation of Zn in ageing and in age-related degenerative diseases corrects immune defects, reduces infection relapse and prevents ageing.

Zinc: role in immunity, oxidative stress and chronic inflammation

  • A. Prasad
  • Medicine, Biology
    Current opinion in clinical nutrition and metabolic care
  • 2009
Zinc supplementation was effective in decreasing oxidative stress and generation of inflammatory cytokines such as TNF-α and IL-1β in elderly individuals and patients with SCD and decreasing incidences of respiratory tract infections in children.

Zinc, metallothioneins and immunosenescence: effect of zinc supply as nutrigenomic approach

Old C− subjects are likely to benefit more from zinc supplementation restoring NK cell cytotoxicity and improving the zinc status, suggesting that the genetic variations of IL-6 and MT1A are very useful tools for the identification of old people who effectively need zinc supplementation.

The significance of zinc for leukocyte biology

Data show that the zinc concentration should be taken into account whenever complex alterations of immune functions are observed and that the therapeutic use of zinc is critically discussed with new aspects also using the immunosuppressive effects of zinc.

Trace elements in human physiology and pathology: zinc and metallothioneins.

  • H. TapieroK. Tew
  • Biology
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  • 2003

The immune system and the impact of zinc during aging

Oral zinc supplementation demonstrates the potential to improve immunity and efficiently downregulates chronic inflammatory responses in the elderly, and indicates that a wide prevalence of marginal zinc deficiency in elderly people may contribute to immunosenescence.

The Essential Toxin: Impact of Zinc on Human Health

Rather than being a toxic metal ion, zinc is an essential trace element and plays a significant role in cytotoxic events in single cells in the brain, and cytotoxicity in consequence of ischemia or trauma involves the accumulation of free zinc.

Zinc and the immune system

The relationship between Zn and the immune system is complex, since there are four different types of influence associated with Zn, which influence the function of immunostimulants used in the experimental systems and the therapeutic use of Zn will be discussed in detail.

Zinc: A promising agent in dietary chemoprevention of cancer

The present review provides an insight into the research conducted on animals as well as on human subjects for providing the concept that zinc deficiency is an important factor in the development and progression of malignancy and that zinc could be efficacious in the prevention and treatment of several cancers.

Intracellular zinc homeostasis and zinc signaling

The current understanding of the roles of Zn homeostasis and signaling primarily in immune cells is summarized, with a discussion of the contributions of these processes to oncogenesis.