Zinc and flunitrazepam modulation of GABA-mediated currents in rat suprachiasmatic neurons.

  title={Zinc and flunitrazepam modulation of GABA-mediated currents in rat suprachiasmatic neurons.},
  author={G. J. Strecker and W. K. Park and F. Dudek},
  journal={Journal of neurophysiology},
  volume={81 1},
  • G. J. Strecker, W. K. Park, F. Dudek
  • Published 1999
  • Chemistry, Medicine
  • Journal of neurophysiology
  • The suprachiasmatic nucleus (SCN) of the hypothalamus is responsible for generating circadian rhythms in mammals, and GABA is the predominant neurotransmitter in the SCN. Properties of gamma-aminobutyric acid-A (GABAA) responses in SCN neurons were examined in acutely prepared hypothalamic slices from 3- to 8-wk-old rats with the use of whole cell voltage-clamp techniques. Zn2+ reduced the amplitude of GABAA-mediated spontaneous inhibitory postsynaptic currents (sIPSCs) in a concentration… CONTINUE READING
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