Zinc: The brain's dark horse
A greater understanding of zinc's role in the central nervous system may allow for the development of therapeutic approaches where aberrant metal homeostasis is implicated in disease pathogenesis, and in fact its role may be underappreciated.
Zinc in the Brain: Friend or Foe?
- BiologyInternational journal of molecular sciences
Zinc is a biological component that plays an important physiological role in the central nervous system, but a pathophysiological role in major neurological disorders, and this review focuses on the multiple roles of zinc in the brain.
Zinc Signal in Brain Functions
The homeostasis of synaptic Zn2+ signal is critical in both functional and pathological aspects and the physiological significance of intracellular Zn 2+ signaling in brain functions, especially in cognition is summarized.
The Neurophysiology and Pathology of Brain Zinc
- Biology, MedicineThe Journal of Neuroscience
The most recent findings that link zinc to synaptic function as well as the injurious effects of zinc dyshomeostasis within the context of neuronal death associated with major human neurological disorders, including stroke, epilepsy, and Alzheimer's disease are reviewed.
Examination of Zinc in the Circadian System
Melanopsin-containing retinal ganglion cells in the mouse retina were found to colocalize ZnT3, indicating that they can release zinc at their synaptic targets and highlight the presence of zinc in areas critical for circadian functioning but have yet to identify a role for zinc in these areas.
The zinc paradigm for metalloneurochemistry.
- Biology, ChemistryEssays in biochemistry
Development and improvement of methods which allow for precise detection and immediate manipulation of zinc ions in neuronal cells and in brain slices will be critical in uncovering the synaptic action of zinc and, more broadly, the bioinorganic chemistry of cognition.
AMPA receptor inhibition by synaptically released zinc
- BiologyProceedings of the National Academy of Sciences
Evidence that endogenous zinc, released by single presynaptic action potentials, inhibits synaptic AMPA currents in the dorsal cochlear nucleus (DCN) and hippocampus is provided, establishing zinc as an activity-dependent, endogenous modulator of AMPARs that tunes fast excitatory neurotransmission and plasticity in glutamatergic synapses.
Dynamic action of neurometals at the synapse.
- BiologyMetallomics : integrated biometal science
The action of metals in synaptic neurotransmission focused on calcium signaling at glutamatergic synapses is summarized to highlight the importance of zinc signaling in the intracellular compartment.
Zinc signaling in the hippocampus and its relation to pathogenesis of depression.
- BiologyJournal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements
Cognitive decline due to excess synaptic Zn2+ signaling in the hippocampus
- BiologyFront. Aging Neurosci.
An overview of the ``Hypothesis and Theory'' of Zn2+-mediated modification of cognitive activity is provided, which indicates an increase in HPA axis activity may induce excess intracellular Zn 2+ signaling in the hippocampus, followed by hippocampus-dependent memory deficit.
SHOWING 1-10 OF 244 REFERENCES
Distribution of zincergic neurons in the mouse forebrain
- BiologyThe Journal of comparative neurology
Synaptically released zinc is thought to play an important role in neuronal signaling by modulating excitatory and inhibitory receptors and intracellular signaling proteins. Consequently, neurons…
A physiological role for endogenous zinc in rat hippocampal synaptic neurotransmission
The study implies that zinc modulates synaptic transmission in the immature hippocampus, a finding that may have implications for understanding benign postnatal seizures in young children suffering with acute zinc deficiency18.
Experience-dependent regulation of synaptic zinc is impaired in the cortex of aged mice
Importance of zinc in the central nervous system: the zinc-containing neuron.
- BiologyThe Journal of nutrition
The present review outlines the methods used to discover, define and describe zinc-containing neurons; the neuroarchitecture and synaptology of zinc- containing neural circuits; the physiology of regulated vesicular zinc release; the "life cycle" and molecular biology of vesicle zinc; the importance of synaptically released zinc in the normal and pathological processes of the cerebral cortex; and the role of specific and nonspecific stressors in the release of zinc.
Neurobiology of zinc and zinc-containing neurons.
- BiologyInternational review of neurobiology
Expression and regulation of brain metallothionein
- BiologyNeurochemistry International
- BiologyBiological signals
Zinc ions are potent modulators of amino acid receptors [especially the N-methyl-D-aspartate (NMDA) receptor] and corelease of zinc along with glutamate would provide a mechanism for modulating postsynaptic excitability levels.
Modulation of synaptic zinc in barrel cortex by whisker stimulation