Zinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluid.

@article{Strozyk2009ZincAC,
  title={Zinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluid.},
  author={Dorothea Strozyk and Lenore J. Launer and Paul A. Adlard and Robert Alan Cherny and Andrew Tsatsanis and Irene Volitakis and K Blennow and Helen Petrovitch and Lon R. White and Ashley I. Bush},
  journal={Neurobiology of aging},
  year={2009},
  volume={30 7},
  pages={1069-77}
}
Abnormal interaction of beta-amyloid 42 (Abeta42) with copper, zinc and iron induce peptide aggregation and oxidation in Alzheimer's disease (AD). However, in health, Abeta degradation is mediated by extracellular metalloproteinases, neprilysin, insulin degrading enzyme (IDE) and matrix metalloproteinases. We investigated the relationship between levels of Abeta and biological metals in CSF. We assayed CSF copper, zinc, other metals and Abeta42 in ventricular autopsy samples of Japanese… CONTINUE READING

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