Zinc and copper influence excitability of rat olfactory bulb neurons by multiple mechanisms.

@article{Horning2001ZincAC,
  title={Zinc and copper influence excitability of rat olfactory bulb neurons by multiple mechanisms.},
  author={Michelle S. Horning and Paul Q. Trombley},
  journal={Journal of neurophysiology},
  year={2001},
  volume={86 4},
  pages={
          1652-60
        }
}
Zinc and copper are highly concentrated in several mammalian brain regions, including the olfactory bulb and hippocampus. Whole cell electrophysiological recordings were made from rat olfactory bulb neurons in primary culture to compare the effects of zinc and copper on synaptic transmission and voltage-gated ion channels. Application of either zinc or copper eliminated GABA-mediated spontaneous inhibitory postsynaptic potentials. However, in contrast to the similarity of their effects on… 

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