Zinc and copper complexes of prodigiosin: implications for copper-mediated double-strand DNA cleavage.

@article{Park2003ZincAC,
  title={Zinc and copper complexes of prodigiosin: implications for copper-mediated double-strand DNA cleavage.},
  author={G Barratt Park and John T Tomlinson and Matt S. Melvin and Marcus Wright and Cynthia S. Day and Richard A Manderville},
  journal={Organic letters},
  year={2003},
  volume={5 2},
  pages={113-6}
}
[reaction: see text] Zinc(II) and copper(II) complexes of prodigiosin (1) have been characterized. All N-atoms of 1 bind Cu(II) to generate 5: the complex exhibits regiospecific oxidation of the C-pyrrole. In contrast, coordination by Zn(II) to 1 produces Zn(1)(2) (8), a 4-coordinate tetrahedral complex. The influence of these binding geometries on Cu-mediated double-strand (ds) DNA cleavage by 1 is discussed. 

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
7 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…