Zinc- and Copper-Induced Interleukin-6 Release in Primary Cell Cultures From Rat Heart

@article{Ansteinsson2009ZincAC,
  title={Zinc- and Copper-Induced Interleukin-6 Release in Primary Cell Cultures From Rat Heart},
  author={Vibeke E Ansteinsson and Magne Refsnes and Tor Skomedal and Jan Bj\orn Osnes and Iwona G Schiander and Marit L{\aa}g},
  journal={Cardiovascular Toxicology},
  year={2009},
  volume={9},
  pages={86-94}
}
The metals, zinc (Zn2+) and copper (Cu2+) from inhaled particulate matter may reach the systemic circulation and the cardiac tissue. In the present study, the potential of Zn2+ and Cu2+ to induce interleukin (IL)-6 responses in cardiomyocytes (CMs) and cardiac fibroblasts (CFs), in mono- and cocultures, was examined. Both metals induced IL-6 release in a concentration (20–200 μM)-dependent manner. Zn2+ appeared more potent than Cu2+ in both mono- and cocultures of CMs and CFs. In the cocultures… CONTINUE READING
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