Zinc and Alzheimer's disease: is there a direct link?

  title={Zinc and Alzheimer's disease: is there a direct link?},
  author={Math P Cuajungco and G. J. Lees},
  journal={Brain research. Brain research reviews},
  volume={23 3},
Zinc is an essential trace element in human biology, but is neurotoxic at high concentrations. Several studies show that zinc promotes aggregations of beta-amyloid protein, the main component of the senile plaques typically found in Alzheimer's disease brains. In other neurological disorders where neurons appear to be dying by apoptosis (gene-directed cell death), chelatable zinc accumulates in the perikarya of neurons before, or during degeneration. As there is evidence for apoptotic death of… CONTINUE READING