Zinc acetate/carrageenan gels exhibit potent activity in vivo against high-dose herpes simplex virus 2 vaginal and rectal challenge.

@article{FernndezRomero2012ZincAG,
  title={Zinc acetate/carrageenan gels exhibit potent activity in vivo against high-dose herpes simplex virus 2 vaginal and rectal challenge.},
  author={Jos{\'e} A Fern{\'a}ndez-Romero and C. Johny Abraham and Aixa Rodr{\'i}guez and Larisa Kizima and Ninochka Jean-Pierre and Radhika Menon and Othell Begay and Samantha Seidor and Brian Elwood Ford and Pedro Ignacio Gil and Jennifer Margaret Peters and David P. Katz and Melissa Pope. Robbiani and Thomas M. Zydowsky},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 1},
  pages={
          358-68
        }
}
Topical microbicides that block the sexual transmission of HIV and herpes simplex virus 2 (HSV-2) are desperately needed to reduce the incidence of HIV infections worldwide. Previously we completed phase 3 testing of the carrageenan-based gel Carraguard. Although the trial did not show that Carraguard is effective in preventing HIV transmission during vaginal sex, it did show that Carraguard is safe when used weekly for up to 2 years. Moreover, Carraguard has in vitro activity against human… CONTINUE READING

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