Zinc Supplementation Modifies Tight Junctions and Alters Barrier Function of CACO-2 Human Intestinal Epithelial Layers

@article{Wang2012ZincSM,
  title={Zinc Supplementation Modifies Tight Junctions and Alters Barrier Function of CACO-2 Human Intestinal Epithelial Layers},
  author={Xuexuan Wang and Mary Carmen Valenzano and Joanna M. Mercado and E. Peter Zurbach and James M Mullin},
  journal={Digestive Diseases and Sciences},
  year={2012},
  volume={58},
  pages={77-87}
}
Zinc deficiency is known to result in epithelial barrier leak in the GI tract. Precise effects of zinc on epithelial tight junctions (TJs) are only beginning to be described and understood. Along with nutritional regimens like methionine-restriction and compounds such as berberine, quercetin, indole, glutamine and rapamycin, zinc has the potential to function as a TJ modifier and selective enhancer of epithelial barrier function. The purpose of this study was to determine the effects of zinc… CONTINUE READING
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