Zinc Is Involved in Depression by Modulating G Protein-Coupled Receptor Heterodimerization

  title={Zinc Is Involved in Depression by Modulating G Protein-Coupled Receptor Heterodimerization},
  author={Merc{\`e} Tena-Campos and Eva Ramon and Cecylia S. Lupala and Juan Jes{\'u}s P{\'e}rez and Karl-W. Koch and Pere Garriga},
  journal={Molecular Neurobiology},
5-Hydroxytryptamine 1A receptor and galanin receptor 1 belong to the G protein-coupled receptors superfamily, and they have been described to heterodimerize triggering an anomalous physiological state that would underlie depression. Zinc supplementation has been widely reported to improve treatment against major depressive disorder. Our work has focused on the study and characterization of these receptors and its relationships with zinc both under purified conditions and in cell culture. To… CONTINUE READING
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