Zinc Finger Recombinases with Adaptable DNA Sequence Specificity

  title={Zinc Finger Recombinases with Adaptable DNA Sequence Specificity},
  author={Chris Proudfoot and Arlene L. McPherson and Andreas F. Kolb and W. Marshall Stark},
  booktitle={PloS one},
Site-specific recombinases have become essential tools in genetics and molecular biology for the precise excision or integration of DNA sequences. However, their utility is currently limited to circumstances where the sites recognized by the recombinase enzyme have been introduced into the DNA being manipulated, or natural 'pseudosites' are already present. Many new applications would become feasible if recombinase activity could be targeted to chosen sequences in natural genomic DNA. Here we… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
19 Extracted Citations
27 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 19 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 27 references

The resolvases and DNA invertases: a family of enzymes involved in site-specific recombination

  • GF Hatfull
  • Genetic Recombination. Washington DC: American…
  • 1988
Highly Influential
4 Excerpts

Site-specific recombinases as instruments for genomic surgery

  • A Akopian, WM Stark
  • Adv Genet
  • 2005
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…