Zinc Finger Recombinases with Adaptable DNA Sequence Specificity

@inproceedings{Proudfoot2011ZincFR,
  title={Zinc Finger Recombinases with Adaptable DNA Sequence Specificity},
  author={Chris Proudfoot and Arlene L. McPherson and Andreas F. Kolb and W. Marshall Stark},
  booktitle={PloS one},
  year={2011}
}
Site-specific recombinases have become essential tools in genetics and molecular biology for the precise excision or integration of DNA sequences. However, their utility is currently limited to circumstances where the sites recognized by the recombinase enzyme have been introduced into the DNA being manipulated, or natural 'pseudosites' are already present. Many new applications would become feasible if recombinase activity could be targeted to chosen sequences in natural genomic DNA. Here we… CONTINUE READING

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