Zinc Activates TREK-2 Potassium Channel Activity

@article{Kim2005ZincAT,
  title={Zinc Activates TREK-2 Potassium Channel Activity},
  author={Jin-Sung Kim and Jin-Yong Park and Ho-Won Kang and Eun-Jung Lee and H. Bang and Jung-Ha Lee},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2005},
  volume={314},
  pages={618 - 625}
}
TWIK-related K+ channel (TREK)-2 is thought to contribute to setting the resting membrane potential and to tuning action potential properties. In the present study, the effects of divalent metal ions (Ba2+, Co2+, Ni2+, Pb2+, and Zn2+) were examined on TREK-2 expressed in Xenopus oocytes using the two-electrode voltage clamping technique. Pb2+ inhibited TREK channel activity (IC50 = 15.6 μM), whereas Zn2+ enhanced it in a dose-dependent manner (EC50 = 87.1 μM). Ba2+ slightly inhibited TREK… Expand
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