Zinc–Ligand Interactions Modulate Assembly and Stability of the Insulin Hexamer – A Review

@article{Dunn2005ZincLigandIM,
  title={Zinc–Ligand Interactions Modulate Assembly and Stability of the Insulin Hexamer – A Review},
  author={M. F. Dunn},
  journal={Biometals},
  year={2005},
  volume={18},
  pages={295-303}
}
  • M. F. Dunn
  • Published 2005
  • Chemistry, Medicine
  • Biometals
  • Zinc and calcium ions play important roles in the biosynthesis and storage of insulin. Insulin biosynthesis occurs within the β-cells of the pancreas via preproinsulin and proinsulin precursors. In the golgi apparatus, proinsulin is sequestered within Zn2+- and Ca2+-rich storage/secretory vesicles and assembled into a Zn2+ and Ca2+ containing hexameric species, (Zn2+)2(Ca2+)(Proin)6. In the vesicle, (Zn2+)2(Ca2+)(Proin)6 is converted to the insulin hexamer, (Zn2+)2(Ca2+)(In)6, by excision of… CONTINUE READING
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