Zinc: The brain's dark horse

  title={Zinc: The brain's dark horse},
  author={Byron K. Y. Bitanihirwe and Miles Cunningham},
Zinc is a life‐sustaining trace element, serving structural, catalytic, and regulatory roles in cellular biology. It is required for normal mammalian brain development and physiology, such that deficiency or excess of zinc has been shown to contribute to alterations in behavior, abnormal central nervous system development, and neurological disease. In this light, it is not surprising that zinc ions have now been shown to play a role in the neuromodulation of synaptic transmission as well as in… 

Zinc in the Brain: Friend or Foe?

Zinc is a biological component that plays an important physiological role in the central nervous system, but a pathophysiological role in major neurological disorders, and this review focuses on the multiple roles of zinc in the brain.

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The development of views on zinc as an essential trace element is analyzed, from the demonstration of its catalytic, metabolic, and structural function to the elucidation of its regulatory role in intra- and inter-neuronal interactions.

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Zinc's roles in brain function are poorly understood, but it is known however that low fetal growth, a process caused by maternal zinc deficiency, is risk factor for coronary heart disease, type 2 diabetes mellitus, chronic lung disease, and obesity.

Brain, aging and neurodegeneration: Role of zinc ion availability

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Zinc and cortical plasticity

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