• Corpus ID: 43828617

Zinc: A Miracle Element. Its Discovery and Impact on Human Health

  title={Zinc: A Miracle Element. Its Discovery and Impact on Human Health},
  author={Ananda S Prasad},
AMP: Deaminase Adenosine Monophosphate Deaminase; ATP 7B: Membrane-Bound Copper-Binding Adenosine Triphosphatase; cGMP: Guanosine 3’, 5’ Cyclic Monophosphate; DC: Dendritic Cells; DNA: Deoxyribonucleic Acid; dTMP: Deoxythymidine 5’ Mono-Phosphate; HL-60: Human promyelocytic Leukemia cell line; HUT-78: Human malignant lymphoblastoid cell line of Th0 phenotype; ICAM-1: Soluble Intercellar Adhesion Molecule-1; IFN-γ: Interferon-γ; IL: Interleukin; IGF-1: Insulin-like Growth Factor 1; IL-1… 

Zinc homeostasis in immunity and its association with preterm births

The present review aims to focus on the understanding of relationship of micronutrient zinc homeostasis in immunity and its association with preterm births.

A Common Insecticide Induced-Oxidative Stress in Wistar Rats: Significance for Humans and Implications for Nutritional Modulation of Insecticide Toxicity

Exposure of rats to Baygon® elicited alteration of key trace elements involved in the antioxidant system, culminating in oxidative stress with attendant deleterious effects, holding great promise in tropical developing countries.

Binding Analysis of Human Immunoglobulin G as a Zinc-Binding Protein

It is suggested that animal IgGs, including human, specifically bind zinc ions, probably through a zinc-binding site in the F(c) fragment and not in the Fab fragment, and IgG and fibrinogen interact with each other and/orbind zinc ions through different mechanisms.

Serum zinc levels of hospitalized children with acute diarrhea differ by the isolated viruses

Viruses contribute largely to etiology of acute diarrhea in Nigerian under-five children, and zinc deficiency was also highly prevalent in the study population.

Peningkatan Kadar Zn Beras Pecah-Kulit pada Sistem Penggenangan Berselang Melalui Aplikasi Pupuk Kandang Diperkaya Zn Heptahidrat

Zn levels in rice are essential for maintaining consumer health. However, Zn deficient plants can reduce levels of Zn in grains and the ability of plants to express their genetic potentials. This

Comparison study between colorimetric method and flame atomic absorption spectrophotometry in serum zinc status

The serum concentrations of zinc of 93 patients with chronic diseases were used for analysis and Pearson correlation coefficient and concordance correlation coefficient were valued and for hypozincemia, the differences were studied and Cohen’s Kappa index was used.

Inhibitory effect of transferrin on serum zinc measurement

Bovine apo-transferrin (Tf) dose-dependently inhibited zinc (Zn) measurement if apo-Tf was added to a Zn standard solution followed by Zn measurement using a commercial Zn assay kit. Incubation of



Zinc-suppressed inflammatory cytokines by induction of A20-mediated inhibition of nuclear factor-κB.

Zinc deficiency affects cell cycle and deoxythymidine kinase gene expression in HUT-78 cells.

Picomolar Concentrations of Free Zinc(II) Ions Regulate Receptor Protein-tyrosine Phosphatase β Activity*

It is demonstrated that zinc(II) ions are reversible inhibitors of the cytoplasmic catalytic domain of the receptor protein-tyrosine phosphatase β, suggesting that zinc regulates this enzyme, which is involved in vascular physiology and angiogenesis.

Toll-like receptor–mediated regulation of zinc homeostasis influences dendritic cell function

It is shown that stimulation with the Toll-like receptor 4 agonist lipopolysaccharide (LPS) altered the expression of zinc transporters in dendritic cells and thereby decreased intracellular free zinc, establishing a link between Toll- like receptor signaling and zinc homeostasis.

Intracellular free zinc up-regulates IFN-γ and T-bet essential for Th1 differentiation in Con-A stimulated HUT-78 cells.

Zinc biochemistry: from a single zinc enzyme to a key element of life.

  • W. Maret
  • Chemistry, Biology
    Advances in nutrition
  • 2013
It is fair to conclude that the impact of zinc for health and disease will be at least as far-reaching as that of iron.

The role of zinc in growth and cell proliferation.

Evidence suggests that reduced zinc availability affects membrane signaling systems and intracellular second messengers that coordinate cell proliferation in response to IGF-I, and may directly regulate DNA synthesis through these systems.

Zinc in Cancer Prevention

In patients with head and neck cancer, it is shown that nearly 65% of these patients were zinc deficient based on their cellular zinc concentrations and zinc status was a better indicator of tumor burden and stage of disease in comparison to the overall nutritional status.

Discovery of Human Zinc Deficiency: Its Impact on Human Health and Disease123

  • A. Prasad
  • Medicine, Biology
    Advances in nutrition
  • 2013
Zinc has been very successfully used as a therapeutic modality for the management of acute diarrhea in children, Wilson’s disease, the common cold and for the prevention of blindness in patients with age-related dry type of macular degeneration and is very effective in decreasing the incidence of infection in the elderly.

Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans.

It is concluded that an imbalance between TH1 and TH2 cells, decreased recruitment of T naive cells, and decreased percentage of T cytolytic cells may account for decreased cell-mediated immune functions in zinc-deficient subjects.