Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study

@article{Weyenbergh2004ZinccopperIR,
  title={Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study},
  author={Johan Van Weyenbergh and Gis{\'e}lia Santana and A D'oliveira and An{\'i}bal de Freitas Santos and Carlos Costa and Edgar Marcelino de Carvalho and Aldina Barral and Manoel Barral-Netto},
  journal={BMC Infectious Diseases},
  year={2004},
  volume={4},
  pages={50 - 50}
}
BACKGROUND The process of elimination of intracellular pathogens, such as Leishmania, requires a Th1 type immune response, whereas a dominant Th2 response leads to exacerbated disease. Experimental human zinc deficiency decreases Th1 but not Th2 immune response. We investigated if zinc and copper levels differ in different clinical forms of leishmaniasis, and if these trace metals might be involved in the immune response towards the parasite. METHODS Blood was collected from 31 patients with… CONTINUE READING
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