Zili is required for germ cell differentiation and meiosis in zebrafish.

@article{Houwing2008ZiliIR,
  title={Zili is required for germ cell differentiation and meiosis in zebrafish.},
  author={Saskia Houwing and Eugene Berezikov and Ren{\'e} F Ketting},
  journal={The EMBO journal},
  year={2008},
  volume={27 20},
  pages={2702-11}
}
Small RNAs exert an effect through diverse RNA interference pathways to transcriptionally or post-transcriptionally silence their targets. The Piwi-interacting RNAs (piRNAs) represent a germline-specific small RNA pathway where Piwi proteins themselves are thought to mediate piRNA biosynthesis. Here, we provide strong evidence for a piRNA amplification loop in zebrafish, in which Ziwi and Zili bind piRNAs of opposite polarity. Furthermore, we describe a function for Zili in transposon defense… CONTINUE READING

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