Zileuton, a 5-lipoxygenase inhibitor in rheumatoid arthritis.


The effects of zileuton, a new 5-lipoxygenase inhibitor, on leukotriene generation and clinical response in rheumatoid arthritis (RA) was studied in a 4-week randomized double blind placebo controlled study at 2 academic rheumatology centers. Zileuton decreased the mean (+/- SEM) ionophore induced synthesis of leukotriene B4 at Week 1 by 70% from 191.2… (More)



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@article{Weinblatt1992ZileutonA5, title={Zileuton, a 5-lipoxygenase inhibitor in rheumatoid arthritis.}, author={Mark E Weinblatt and Jacques Kremer and Jonathan S. Coblyn and Simon M Helfgott and Adrian Maier and G. Petrillo and B. Henson and Paul H. Rubin and R. Sperling}, journal={The Journal of rheumatology}, year={1992}, volume={19 10}, pages={1537-41} }