Zika virus protection by a single low dose nucleoside modified mRNA vaccination

@article{Pardi2017ZikaVP,
  title={Zika virus protection by a single low dose nucleoside modified mRNA vaccination},
  author={Norbert Pardi and Michael J Hogan and Rebecca S. Pelc and Hiromi Muramatsu and Hanne Andersen and Christina R DeMaso and Kimberly A. Dowd and Laura L. Sutherland and Richard M Scearce and Robert Parks and Wendeline Wagner and Alex Granados and Jack Greenhouse and Michelle Walker and Elinor Willis and Jae-Sung Yu and Charles E. McGee and Gregory D. Sempowski and Barbara L. Mui and Ying K. Tam and Yan-Jang S. Huang and Dana L Vanlandingham and Veronica M. Holmes and Harikrishnan Balachandran and Sujata Sahu and Michelle A. Lifton and Stephen Higgs and Scott E. Hensley and Thomas D. Madden and Michael J. Hope and Katalin Karik{\'o} and Sampa Santra and Barney S. Graham and Mark G. Lewis and Theodore C. Pierson and Barton F. Haynes and Drew Weissman},
  journal={Nature},
  year={2017},
  volume={543},
  pages={248 - 251}
}
Zika virus (ZIKV) has recently emerged as a pandemic associated with severe neuropathology in newborns and adults. There are no ZIKV-specific treatments or preventatives. Therefore, the development of a safe and effective vaccine is a high priority. Messenger RNA (mRNA) has emerged as a versatile and highly effective platform to deliver vaccine antigens and therapeutic proteins. Here we demonstrate that a single low-dose intradermal immunization with lipid-nanoparticle-encapsulated nucleoside… 
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