Zika virus directly infects peripheral neurons and induces cell death

  title={Zika virus directly infects peripheral neurons and induces cell death},
  author={Yohan Oh and Feiran Zhang and Yaqing Wang and E. Lee and I. Choi and Hotae Lim and Fahimeh Mirakhori and Rong-hua Li and L. Huang and Tianlei Xu and H. Wu and C. Li and Chengfeng Qin and Zhexing Wen and Qing-feng Wu and Hengli Tang and Zhi-heng Xu and Peng Jin and H. Song and G. Ming and Gabsang Lee},
  journal={Nature neuroscience},
  pages={1209 - 1212}
  • Yohan Oh, Feiran Zhang, +18 authors Gabsang Lee
  • Published 2017
  • Biology, Medicine
  • Nature neuroscience
  • Zika virus (ZIKV) infection is associated with neurological disorders of both the CNS and peripheral nervous systems (PNS), yet few studies have directly examined PNS infection. Here we show that intraperitoneally or intraventricularly injected ZIKV in the mouse can infect and impact peripheral neurons in vivo. Moreover, ZIKV productively infects stem-cell-derived human neural crest cells and peripheral neurons in vitro, leading to increased cell death, transcriptional dysregulation and cell… CONTINUE READING
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