Zika virus–related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice

@article{Platt2018ZikaVN,
  title={Zika virus–related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice},
  author={Derek J Platt and Amber M. Smith and Nitin Arora and Michael S Diamond and Carolyn B Coyne and Jonathan J Miner},
  journal={Science Translational Medicine},
  year={2018},
  volume={10}
}
Although Zika virus (ZIKV) infection in pregnant women can cause placental damage, intrauterine growth restriction, microcephaly, and fetal demise, these disease manifestations only became apparent in the context of a large epidemic in the Americas. We hypothesized that ZIKV is not unique among arboviruses in its ability to cause congenital infection. To evaluate this, we tested the capacity of four emerging arboviruses [West Nile virus (WNV), Powassan virus (POWV), chikungunya virus (CHIKV… CONTINUE READING
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BOX Birth defects potentially related to Zika virus infection Brain abnormalities with and without microcephaly

Christie L. Walker, Marie-Térèse E. Little, +9 authors Kristina M. Adams Waldorf
  • 2018
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