Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation.

@article{Li2016ZikaVI,
  title={Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation.},
  author={Hongda Li and Laura Paula Saucedo-Cuevas and Jose Angel Regla-Nava and Guoliang Chai and Nicholas W Sheets and William Weihao Tang and Alexey V. Terskikh and Sujan Shresta and Joseph G Gleeson},
  journal={Cell stem cell},
  year={2016},
  volume={19 5},
  pages={
          593-598
        }
}
Zika virus (ZIKV)-related neuropathology is an important global health concern. Several studies have shown that ZIKV can infect neural stem cells in the developing brain, but infection in the adult brain has not been examined. Two areas in the adult mouse brain contain neural stem cells: the subventricular zone of the anterior forebrain and the subgranular zone of the hippocampus. Here, using 6-week-old mice triply deficient in interferon regulatory factor (IRF) as a model, we show that blood… CONTINUE READING

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