Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice.

  title={Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice.},
  author={Cui Li and Dan Xu and Qing Ye and Shuai Hong and Yisheng Jiang and Xinyi Liu and Nana Zhang and Lei Shi and Cheng-Feng Qin and Zhiheng Xu},
  journal={Cell stem cell},
  volume={19 5},
Zika Virus Disrupts Phosp ho-TBK 1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia Graphical Abstract Highlights
It is found that ZikV predominantly infects NES and radial glial cells, a pivotal role for pTBK1 is revealed, and nucleoside analogs inhibit ZIKV replication, protecting NES cells from cell death.
Zika virus‐induced brain malformations in chicken embryos
Chicken embryos were chosen as experimental model of ZIKV to evaluate virus‐associated morphological alterations that might take place during embryonic development.
Zika virus induces astrocyte differentiation in neural stem cells
Molecular and cellular evidence is provided that ZIKV significantly alters neural development in the vertebrate host and that astrocyte differentiation may be a protective response that limits neuropathogenesis.
ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly and p53
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Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures
Integrated analyses of differentially expressed genes and miRNAs showed that ZIKV infection had an impact on processes associated with neurodevelopment and oxidative stress, and insights are provided into the roles of intracellular and EV-associated host mi RNAs in ZikV pathogenesis.
Differential Responses of Human Fetal Brain Neural Stem Cells to Zika Virus Infection
Zika in the Brain: New Models Shed Light on Viral Infection.
Zika virus impairs the development of blood vessels in a mouse model of congenital infection
The results indicate that ZIKV impairs angiogenesis in addition to neurogenesis during development, and the vasculature defects represent a limitation for general brain growth but also could regulate Neurogenesis directly.