Zika Virus Disease: A CDC Update for Pediatric Health Care Providers

@article{Karwowski2016ZikaVD,
  title={Zika Virus Disease: A CDC Update for Pediatric Health Care Providers},
  author={Mateusz P. Karwowski and Jennifer M Nelson and J. Erin Staples and Marc Fischer and Katherine E Fleming-Dutra and Julie Villanueva and Ann M Powers and Paul S Mead and Margaret A. Honein and Cynthia A Moore and Sonja A. Rasmussen},
  journal={Pediatrics},
  year={2016},
  volume={137}
}
Zika virus is a mosquito-borne flavivirus discovered in Africa in 1947. Most persons with Zika virus infection are asymptomatic; symptoms when present are generally mild and include fever, maculopapular rash, arthralgia, and conjunctivitis. Since early 2015, Zika virus has spread rapidly through the Americas, with local transmission identified in 31 countries and territories as of February 29, 2016, including several US territories. All age groups are susceptible to Zika virus infection… 
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An Update on the Transmission, Pathogenesis, Diagnosis, Treatment and Prevention of Zika Virus Infection
TLDR
The current understanding about the transmission, pathogenesis, clinical features, and diagnosis of Zika virus infection is described.
Zika Virus Infection: A Vector-Borne Threat to Pregnant Women and Infants
TLDR
Although largely a self-limiting disease usually without symptoms, pregnant women and their fetuses are at greatest risk of ZIKV infection, and available evidence suggests that infection during the first trimester of pregnancy is associated with higher risk of brain abnormalities and perinatal loss.
Zika Virus Disease: Case Report and Review of Literature
TLDR
It is critical for physicians and other providers to know the growing list of countries and territories on the US Centers for Disease Control and Prevention list of nations with endemic ZIKV disease and to work closely with local health departments to prevent spread.
Clinical aspects of Zika virus
TLDR
The current ZIKV outbreak has illustrated the emergent capabilities of mosquito-borne viruses and the teratogenic nature of ZIKVs, and infants have been uniquely impacted by the current outbreak with significant congenital exposure resulting in permanent neurological defects and developmental complications.
Zika virus infection: epidemiology, clinical manifestations and diagnosis
TLDR
The findings illustrate the emergence of a viral disease with the identification of new associated disorders, new modes of transmission, including maternal–foetal and sexual transmission.
Understanding Zika virus
  • J. Murray
  • Medicine
    Journal for specialists in pediatric nursing : JSPN
  • 2017
TLDR
An infectious threat that was relatively obscure just a few months ago has now become a topic of heightened interest worldwide and Pediatric healthcare professionals must remain cognizant of evolving developments and emerging new evidence.
Zika Virus Disease Comparing Children and Adults in a Dengue-Endemic Setting
TLDR
In dengue-endemic settings, rash and fever in children, and rash, arthralgia, and conjunctivitis in adults, particularly if rash persists for ≥ 3 days, plus negative denge NS1 Ag during early febrile phase should prompt ZIKV diagnostic testing.
Clinical Impact of Non-Congenital Zika Virus Infection in Infants and Children
  • S. Hagmann
  • Medicine
    Current Infectious Disease Reports
  • 2017
TLDR
Most symptomatic non-congenital ZIKV infection in infants and children is mild and self-limited, but long-term follow-up studies are lacking, and the mechanism and impact of perinatal and breast milk transmission is unclear.
Zika Virus, Congenital Infection, and Neurologic Manifestations in Children: A Narrative Review
Context: Zika virus (ZIKV) is an arbovirus of the family Flaviviridae. This virus, which is transmitted by mosquitoes, usually affects children and causes self-limited diseases, associated with…
The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact
TLDR
The causal link between ZikV infection during pregnancy and microcephaly is now strongly supported and the need for a rapid global public health and research response to ZIKV to limit and prevent its impact through the development of therapeutics, vaccines, and improved diagnostics is highlighted.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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To the Editor: Dengue is the most prevalent arthropod-borne viral disease in tropical and subtropical countries. Every year, dengue virus (DENV) infections cause more than 50 million cases, 500,000…
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TLDR
By January 20, 2016, locally-transmitted cases had been reported to the Pan American Health Organization from Puerto Rico and 19 other countries or territories in the Americas* (Figure) (6).
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