Zika Virus Associated with Microcephaly.

@article{Mlakar2016ZikaVA,
  title={Zika Virus Associated with Microcephaly.},
  author={Jernej Mlakar and Misa Korva and Nata{\vs}a Tul and Mara Popovi{\'c} and Mateja Polj{\vs}ak-Prijatelj and Jerica Mraz and Marko Kolenc and Katarina Resman Rus and Tina Vesnaver Vipotnik and Vesna Fabjan Vodu{\vs}ek and Alenka Vizjak and Jo{\vz}e Pi{\vz}em and Miroslav Petrovec and Tatjana Av{\vs}i{\vc} Županc},
  journal={The New England journal of medicine},
  year={2016},
  volume={374 10},
  pages={
          951-8
        }
}
A widespread epidemic of Zika virus (ZIKV) infection was reported in 2015 in South and Central America and the Caribbean. A major concern associated with this infection is the apparent increased incidence of microcephaly in fetuses born to mothers infected with ZIKV. In this report, we describe the case of an expectant mother who had a febrile illness with rash at the end of the first trimester of pregnancy while she was living in Brazil. Ultrasonography performed at 29 weeks of gestation… 
View on PubMed
comb.cat
2,139 Citations
Highly Influential Citations
105
Background Citations
687
Methods Citations
26
Results Citations
39

2,139 Citations

Citation Type

Citation Type

Congenital Zika Virus Infection: Beyond Neonatal Microcephaly.
TLDR
Combined findings from clinical, laboratory, imaging, and pathological examinations provided a more complete picture of the severe damage and developmental abnormalities caused by ZIKV infection than has been previously reported.
A Zika virus-associated microcephaly case with background exposure to STORCH agents
TLDR
Both mother and microcephaly infant had immunologic status compatible with previous exposure (in the mother) by STORCH agents, which indicates a possible role of previous exposures and possibly comorbidities in the severe fetal congenital manifestation.
The spectrum of neuropathological changes associated with congenital Zika virus infection
TLDR
A comprehensive neuropathological study in ten newborn babies infected with ZIKV during pregnancy, including the spinal cords and dorsal root ganglia, and also muscle, pituitaries, eye, systemic organs, and placentas, indicates a developmental vulnerability of the immature CNS, and sheds light on possible mechanisms of brain injury of this newly recognized public health threat.
Neuropathology of Zika Virus Infection
TLDR
Larger, systematic studies will be required to determine the full range of Zika virus-induced abnormalities and to help guide future clinical decision making.
Zika Virus Infection in Pregnant Women and Microcephaly.
  • G. Duarte, A. Moron, +16 authors R. Francisco
  • Medicine
    Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia
  • 2017
TLDR
There are still no reliable techniques for the serological diagnosis of this infection, and there is no specific antiviral therapy against ZIKV, and the therapeutic approach to infected pregnant women is limited to the use of antipyretics and analgesics.
International Perspectives: Microcephaly and Zika Virus Infection in Brazil
TLDR
Initial research on isolating and sequencing the Zika virus in brains and amniotic liquid of fetuses and newborn infants with microcephaly showed that the virus shares 97% to 100% of its genomic identity with lineages isolated in the outbreak in French Polynesia in 2013.
Zika Virus-Associated Micrencephaly: A Thorough Description of Neuropathologic Findings in the Fetal Central Nervous System.
TLDR
The findings are in agreement with neuroimaging of Zika virus-associated fetal and infant micrencephalic brains and, to some extent, with neuroIMaging of other intrauterine infections causing microcephaly.
Neuroimaging findings of Zika virus infection: a review article
TLDR
Familiarity with neuroimaging findings of congenital and acquired ZIKV infection is crucial to suspect this disease in residents of endemic regions and travelers to these areas.
Zika virus and pregnancy in Brazil: What happened?
TLDR
An insight is provided into the history and evolution of ZIKV in Brazil, including current knowledge concerning the transmission, diagnosis, and pathogenesis of the infection, using ultrasound, magnetic resonance imaging, and computed tomography.
A Possible Association Between Zika Virus Infection and CDK5RAP2 Mutation
TLDR
Molecular and microbiological assessments were used to report the initial case of vertically transmitted ZIKV infection with congenital syndrome associated with a neurological syndrome, where a mutation in the CDK5RAP2 gene was also identified.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 19 REFERENCES
Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg?
TLDR
Examination of two pregnant women from the state of Paraiba who were diagnosed with fetal microcephaly and were considered part of the ‘microCEphaly cluster’ was positive for Zika virus in both patients, most likely representing the first diagnoses of intrauterine transmission of the virus.
Current Zika virus epidemiology and recent epidemics.
Zika virus, French Polynesia, South Pacific, 2013.
TLDR
The discovery of ZIKV as the etiologic agent was not achieved through retrospective testing of serum from patients incorrectly diagnosed as having dengue, but rather the result of an active, coordinated investigation by the Yap State Department of Health Services with instrumental assistance from international partners.
Congenital Arboviral Infections: Something New, Something Old
TLDR
In 1999, West Nile virus (WNV), a member of the JEV antigenic complex of flaviviruses (family Flaviviridae) discovered in 1937, was introduced into the Western hemisphere, paralleling in some respects the emergence of JEV in northern India.
Molecular Evolution of Zika Virus during Its Emergence in the 20th Century
TLDR
Evidence is presented that ZIKV has possibly undergone recombination in nature and that a loss of the N154 glycosylation site in the envelope protein was a possible adaptive response to the Aedes dalzieli vector.
Zika Virus, French Polynesia, South Pacific, 2013
TLDR
Early investigations that led to identification of ZIKV as the causative agent of an outbreak that started in October 2013 in French Polynesia are reported.
Quantitative real-time PCR detection of Zika virus and evaluation with field-caught Mosquitoes
TLDR
This assay is a useful tool for detection of ZIKV infection in regions where a number of other clinically indistinguishable arboviruses like dengue or chikungunya co-circulate.
One-step RT-PCR for detection of Zika virus.
Intrauterine West Nile virus: ocular and systemic findings.
Zika virus outbreak on Yap Island, Federated States of Micronesia.
TLDR
This outbreak of Zika virus illness in Micronesia represents transmission of Zikairus outside Africa and Asia and clinicians and public health officials should be aware of the risk of further expansion of Zika viruses transmission.
...
1
2
...