Zika's passage to India.

@article{Rolph2019ZikasPT,
  title={Zika's passage to India.},
  author={Michael S. Rolph and Suresh Mahalingam},
  journal={The Lancet. Infectious diseases},
  year={2019},
  volume={19 5},
  pages={
          469-470
        }
}
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It appears that the ZIKV strain circulating in India possibly belongs to the “Asian lineage,” which has not yet been associated with microcephaly and other neurological disorders, but there still exists a threat that the contemporary ZikV virulent strain from South America, carrying a mutation can return to Asia, posing a potential crisis to newborns and adult patients.

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It is concluded that the WHO’s removal of the PHEIC designation should not be interpreted as an indication that the threat posed by ZIKV has subsided, and the population at risk of ZikV infection in Asia could be even larger than in the Americas.

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A single serine-to-asparagine substitution in the viral polyprotein substantially increased ZIKV infectivity in both human and mouse neural progenitor cells (NPCs) and led to more severe microcephaly in the mouse fetus, as well as higher mortality rates in neonatal mice.

Case of Microcephaly after Congenital Infection with Asian Lineage Zika Virus, Thailand

The virus genomes from 3 pregnant women in Thailand with Zika virus diagnoses had infections with the Asian lineage, and one woman infected at gestational week 9 had a fetus with microcephaly.

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