Zif268/egr1 gene controls the selection, maturation and functional integration of adult hippocampal newborn neurons by learning.

@article{Veyrac2013Zif268egr1GC,
  title={Zif268/egr1 gene controls the selection, maturation and functional integration of adult hippocampal newborn neurons by learning.},
  author={Alexandra Veyrac and Alexandra Gros and Elodie Bruel-Jungerman and Christelle Rochefort and Felix B Kleine Borgmann and Sebastian Jessberger and Serge Laroche},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 17},
  pages={7062-7}
}
New neurons are continuously added to the dentate gyrus of the adult mammalian brain. During the critical period of a few weeks after birth when newborn neurons progressively mature, a restricted fraction is competitively selected to survive in an experience-dependent manner, a condition for their contribution to memory processes. The mechanisms that control critical stages of experience-dependent functional incorporation of adult newborn neurons remain largely unknown. Here, we identify a… CONTINUE READING
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