Zidovudine transport in the rabbit brain during intravenous and intracerebroventricular infusion.

@article{Wang1995ZidovudineTI,
  title={Zidovudine transport in the rabbit brain during intravenous and intracerebroventricular infusion.},
  author={Yaohua Wang and Ronald J. Sawchuk},
  journal={Journal of pharmaceutical sciences},
  year={1995},
  volume={84 7},
  pages={871-6}
}
The distribution of zidovudine (AZT) between plasma, brain extracellular fluid (ECF), and cerebrospinal fluid (CSF) was investigated in a crossover design study (n = 5) in unanesthetized rabbits. Drug was administered by intravenous (iv) and intracerebroventricular (icv) infusions at the same infusion rate (1.5 mg/h.kg). The concentrations of AZT in ECF and CSF were measured by HPLC with microdialysis sampling. Plasma concentrations of AZT were quantitated by HPLC. Following iv infusion, the… CONTINUE READING

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