• Biology, Medicine
  • Published in Neurotoxicology 1999

Zidovudine [AZT] myotoxicity: quantitative separation of AZT effects on proliferation and differentiation of muscle cells in vitro. Lack of myotoxicity potentiation by retrovirus.

@article{Waclawik1999ZidovudineM,
  title={Zidovudine [AZT] myotoxicity: quantitative separation of AZT effects on proliferation and differentiation of muscle cells in vitro. Lack of myotoxicity potentiation by retrovirus.},
  author={Andrew J. Waclawik and James M. Vann and Georg Schmelz and Paul Francis Szurek and P J Lewandoski and Benjamin R. Brooks},
  journal={Neurotoxicology},
  year={1999},
  volume={20 1},
  pages={
          49-56
        }
}
We compared quantitatively the myotoxicity of 3'-azido-2',3'-dideoxythymidine (AZT) against uninfected and ts1 retrovirus infected mouse skeletal muscle (ATCC CRL 1772) cells at different stages of maturation in vitro. The AZT half inhibitory concentration (IC50) for myoblast proliferation was determined for uninfected myoblasts and parallel cultures infected with ts1 virus. The AZT IC50 for muscle cell differentiation was determined in cultures where myoblasts were grown to confluence and then… CONTINUE READING

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