Zic3 is involved in the left-right specification of the Xenopus embryo.

@article{Kitaguchi2000Zic3II,
  title={Zic3 is involved in the left-right specification of the Xenopus embryo.},
  author={Tetsuya Kitaguchi and Takeki Nagai and Katsunori Nakata and Jun Aruga and Katsuhiko Mikoshiba},
  journal={Development},
  year={2000},
  volume={127 22},
  pages={4787-95}
}
Establishment of left-right (L-R) asymmetry is fundamental to vertebrate development. Several genes involved in L-R asymmetry have been described. In the Xenopus embryo, Vg1/activin signals are implicated upstream of asymmetric nodal related 1 (Xnr1) and Pitx2 expression in L-R patterning. We report here that Zic3 carries the left-sided signal from the… CONTINUE READING