Zic1 promotes the expansion of dorsal neural progenitors in spinal cord by inhibiting neuronal differentiation.

@article{Aruga2002Zic1PT,
  title={Zic1 promotes the expansion of dorsal neural progenitors in spinal cord by inhibiting neuronal differentiation.},
  author={Jun Aruga and Takahide Tohmonda and Shunsaku Homma and Katsuhiko Mikoshiba},
  journal={Developmental biology},
  year={2002},
  volume={244 2},
  pages={329-41}
}
The role of Zic1 was investigated by altering its expression status in developing spinal cords. Zic genes encode zinc finger proteins homologous to Drosophila Odd-paired. In vertebrate neural development, they are generally expressed in the dorsal neural tube. Chick Zic1 was initially expressed evenly along the dorsoventral axis and its expression became increasingly restricted dorsally during the course of neurulation. The dorsal expression of Zic1 was regulated by Sonic hedgehog, BMP4, and… CONTINUE READING

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