Zfx Controls the Self-Renewal of Embryonic and Hematopoietic Stem Cells

@article{GalanCaridad2007ZfxCT,
  title={Zfx Controls the Self-Renewal of Embryonic and Hematopoietic Stem Cells},
  author={Jose M. Galan-Caridad and Sivan Harel and Teresita L Arenzana and Zhiying Esther Hou and Fiona Doetsch and Leonid A. Mirny and Boris Reizis},
  journal={Cell},
  year={2007},
  volume={129},
  pages={345-357}
}
Stem cells (SC) exhibit a unique capacity for self-renewal in an undifferentiated state. It is unclear whether the self-renewal of pluripotent embryonic SC (ESC) and of tissue-specific adult SC such as hematopoietic SC (HSC) is controlled by common mechanisms. The deletion of transcription factor Zfx impaired the self-renewal but not the differentiation capacity of murine ESC; conversely, Zfx overexpression facilitated ESC self-renewal by opposing differentiation. Furthermore, Zfx deletion… CONTINUE READING