Zfrp8, the Drosophila ortholog of PDCD2, functions in lymph gland development and controls cell proliferation.

@article{Minakhina2007Zfrp8TD,
  title={Zfrp8, the Drosophila ortholog of PDCD2, functions in lymph gland development and controls cell proliferation.},
  author={Svetlana Minakhina and Marina K. Druzhinina and R. Steward},
  journal={Development},
  year={2007},
  volume={134 13},
  pages={2387-96}
}
We have identified a new gene, Zfrp8, as being essential for hematopoiesis in Drosophila. Zfrp8 (Zinc finger protein RP-8) is the Drosophila ortholog of the PDCD2 (programmed cell death 2) protein of unknown function, and is highly conserved in all eukaryotes. Zfrp8 mutants present a developmental delay, lethality during larval and pupal stages and hyperplasia of the hematopoietic organ, the lymph gland. This overgrowth results from an increase in proliferation of undifferentiated hemocytes… CONTINUE READING

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