Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles.

@article{Cho2012ZetaPA,
  title={Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles.},
  author={Wan-Seob Cho and Rodger Duffin and Frank Thielbeer and Mark Bradley and Ian L Megson and W. MacNee and Craig A. Poland and Carol T. Tran and Ken Donaldson},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2012},
  volume={126 2},
  pages={469-77}
}
The toxicology of nanoparticles (NPs) is an area of intense investigation that would be greatly aided by improved understanding of the relationship between NP structure and inflammogenicity. To evaluate how their physicochemical parameters influence toxicity, we assembled a panel of 15 metal/metal oxide NPs and attempted to relate various physicochemical parameters, including zeta potential (ζP) and solubility, to lung inflammogenicity. The acute pulmonary inflammogenicity of the 15 NPs showed… CONTINUE READING

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