Corpus ID: 39654917

Zerumbone induces G 1 cell cycle arrest and apoptosis in cervical carcinoma cells

@inproceedings{Zhou2017ZerumboneIG,
  title={Zerumbone induces G 1 cell cycle arrest and apoptosis in cervical carcinoma cells},
  author={Yuzhen Zhou and Wei Tu and Chang Shu and Xiaojie Gu and Yan Huang and Xiao Shen and Hongqing Gu},
  year={2017}
}
Cervical carcinoma is a cancer arising from the cervix, and it is the fourth most common cause of death in women. However, currently the candidate drugs to suppress cervical carcinoma remain lacking. This research was carried out to investigate if zerumbone, a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith, will produce the anticancer effects on cervical carcinoma cell lines. We demonstrated here for the first time that zerumbone significantly suppressed the viability of… Expand

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References

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TLDR
The compound, zerumbone inhibits both cancer cell growth through the induction of apoptosis, arrests cell cycle at G2/M phase and inhibits the secretion levels of IL-6 in both cancer cells. Expand
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TLDR
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Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas‐ and mitochondria‐mediated pathway
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Zerumbone is an inducer of apoptosis in leukemic cells that specifically triggers the Fas/CD95‐ and mitochondria‐mediated apoptotic signaling pathway. Expand
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It is indicated that ZER causes G2/M phase cell cycle arrest and Bax/Bak-mediated apoptosis in human breast cancer cells, and retards growth of MDA-MB-231 xenografts in vivo. Expand
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Zerumbone, a Southeast Asian Ginger Sesquiterpene, Induced Apoptosis of Pancreatic Carcinoma Cells through p53 Signaling Pathway
TLDR
It is found that zerumbone was able to induce apoptosis of pancreatic carcinoma cell lines, indicating to be a promising treatment for pancreatic cancer. Expand
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TLDR
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