Zero-order switches and developmental thresholds

@article{Goldbeter2005ZeroorderSA,
  title={Zero-order switches and developmental thresholds},
  author={Albert Goldbeter},
  journal={Molecular Systems Biology},
  year={2005},
  volume={1},
  pages={2005.0031 - 2005.0031}
}
A long-standing problem in developmental biology, closely associated with pattern formation, is how continuous morphogen gradients are translated into sharp response borders that define clearcut territories in which cells express different sets of genes. To understand how gradients can generate thresholds, several mechanisms have been investigated over the years. Initially, most of these studies were of a theoretical nature, unrelated to any specific example based on solid molecular background… CONTINUE READING