Zeneca ZD7114 acts as an antagonist at beta 3-adrenoceptors in rat isolated ileum.

@article{Growcott1993ZenecaZA,
  title={Zeneca ZD7114 acts as an antagonist at beta 3-adrenoceptors in rat isolated ileum.},
  author={James W Growcott and Brian Holloway and Matt Green and Catherine Wilson},
  journal={British journal of pharmacology},
  year={1993},
  volume={110 4},
  pages={1375-80}
}
1. The relaxant effects of Zeneca ZD7114, BRL37344 (putative beta 3-adrenoceptor agonists) and various phenylethylamine-based agonists were studied in isolated ileum of the rat where tone was increased with carbachol (0.5 microM). Agonist-induced relaxation.was measured under equilibrium conditions with alpha-, beta 1- and beta 2-adrenoceptors inhibited. 2. Relaxant responses were obtained to isoprenaline, noradrenaline, and BRL37344, although, the efficacy of this latter agent was… CONTINUE READING

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