Zelrix™: A Novel Transdermal Formulation of Sumatriptan

  title={Zelrix{\texttrademark}: A Novel Transdermal Formulation of Sumatriptan},
  author={Mark W. Pierce and Thomas C. Marbury and Carol O'neill and Steven J. Siegel and Wei Du and Terri B. Sebree},
  journal={Headache: The Journal of Head and Face Pain},
Objective.— This study evaluated the pharmacokinetic and tolerability profiles of Zelrix™ (NuPathe Inc., Conshohocken, PA, USA), the novel formulation of sumatriptan (formerly known as NP101). 
Twelve‐Month Tolerability and Efficacy Study of NP101, the Sumatriptan Iontophoretic Transdermal System
Objective.— To assess the long‐term tolerability and efficacy of NP101, a novel transdermal sumatriptan patch being developed for the acute treatment of migraine.
Transdermal Sumatriptan for Acute Treatment of Migraineurs With Baseline Nausea
Evaluation of the efficacy and safety of transdermal sumatriptan in migraine patients who have baseline nausea in patients with baseline nausea finds it to be safe and effective.
Subcutaneous Sumatriptan Pharmacokinetics: Delimiting the Monoamine Oxidase Inhibitor Effect
  • A. Fox
  • Medicine, Biology
  • 2010
(Headache 2010;50:249‐255)
The iontophoretic transdermal system formulation of sumatriptan as a new option in the acute treatment of migraine: a perspective
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Sumatriptan Iontophoretic Transdermal System Reduces Treatment‐Emergent Nausea and Is Effective in Patients With and Without Nausea at Baseline – Results From a Randomized Controlled Trial
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A Sumatriptan Iontophoretic Transdermal System for the Acute Treatment of Migraine
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Sumatriptan succinate: pharmacokinetics of different formulations in clinical practice
The new drug formulations that are the most similar to the pharmacokinetics parameters of the subcutaneous sumatriptan are promising because they both improve pharmacokinetic bioavailability bypassing the first-pass metabolism and increase patient compliance.
Sumatriptan iontophoretic transdermal system for the acute treatment of migraine.
This sumatriptan transdermal system may be a good choice for migraineurs with severe nausea or vomiting, those with intolerable triptan-related adverse events and/or those not responding optimally to oral medications.


Bioequivalence and Rapid Absorption of Zolmitriptan Nasal Spray Compared with Oral Tablets in Healthy Japanese Subjects
The rapid absorption of zolmitriptan nasal spray may explain the faster relief from migraine reported in patients compared with oral zolMITriptan.
Multimechanistic (sumatriptan-naproxen) early intervention for the acute treatment of migraine
The fixed-dose single-tablet formulation of sumatriptan/naproxen was effective and well tolerated in an early intervention paradigm for the acute treatment of migraine, including traditional and nontraditional symptoms.
Gastric Stasis in Migraine: More Than Just a Paroxysmal Abnormality During a Migraine Attack
The aim of this article is to evaluate gastric motility and emptying in the ictal and interictal period in migraine.
5-HT1-like receptors: a time to bid goodbye.
Migraine Symptoms: Results of a Survey of Self‐Reported Migraineurs
The most common reported symptoms associated with migraine were pain, nausea, problems with vision, and vomiting, and the most important features of a migraine medication were rapid and effective relief of headache pain, decreasing the likelihood of headache recurrence, and not causing nausea.
Sensitization of meningeal sensory neurons and the origin of headaches
The activity of primary afferent neurons in the rat trigeminal ganglion that innervate the dural venous sinuses are recorded, showing properties of meningeal afferents that may contribute to the intracranial mechanical hypersensitivity that is characteristic of some types of clinically occurring headaches, and to the throbbing pain of migraine.
The International Classification of Headache Disorders
The ICHD identifies and categorizes more than a hundred different kinds of headache in a logical, hierarchal system and has provided explicit diagnostic criteria for all of the headache disorders listed.
Triptans, 5-HT1B/1D receptor agonists in the acute treatment of migraine
  • 2006
A Unique Iontophoretic Patch for Optimal Transdermal Delivery of Sumatriptan
This study met the initial objective to define the dose–current relationship in humans as well as delimiting specific current and current density targets for a well tolerated patch design that can deliver therapeutic drug levels for longer periods than currently possible.