Zelrix™: A Novel Transdermal Formulation of Sumatriptan

@article{Pierce2009ZelrixAN,
  title={Zelrix{\texttrademark}: A Novel Transdermal Formulation of Sumatriptan},
  author={Mark W. Pierce and Thomas C. Marbury and Carol O'neill and Steven J. Siegel and Wei Du and Terri B. Sebree},
  journal={Headache: The Journal of Head and Face Pain},
  year={2009},
  volume={49}
}
Objective.— This study evaluated the pharmacokinetic and tolerability profiles of Zelrix™ (NuPathe Inc., Conshohocken, PA, USA), the novel formulation of sumatriptan (formerly known as NP101). 
View on Wiley
ncbi.nlm.nih.gov
62 Citations
Highly Influential Citations
5
Background Citations
18
Methods Citations
6
Results Citations
3

62 Citations

Twelve‐Month Tolerability and Efficacy Study of NP101, the Sumatriptan Iontophoretic Transdermal System
Objective.— To assess the long‐term tolerability and efficacy of NP101, a novel transdermal sumatriptan patch being developed for the acute treatment of migraine.
Transdermal Sumatriptan for Acute Treatment of Migraineurs With Baseline Nausea
TLDR
Evaluation of the efficacy and safety of transdermal sumatriptan in migraine patients who have baseline nausea in patients with baseline nausea finds it to be safe and effective.
Subcutaneous Sumatriptan Pharmacokinetics: Delimiting the Monoamine Oxidase Inhibitor Effect
  • A. Fox
  • Medicine, Biology
    Headache
  • 2010
(Headache 2010;50:249‐255)
The iontophoretic transdermal system formulation of sumatriptan as a new option in the acute treatment of migraine: a perspective
TLDR
According to pharmacokinetic properties and clinical data, sumatriptan ITS may be a good choice for people with migraine and severe nausea, vomiting or gastroparesis, those with intolerable triptan-related adverse events and those not responding optimally to oral medications.
Sumatriptan Iontophoretic Transdermal System Reduces Treatment‐Emergent Nausea and Is Effective in Patients With and Without Nausea at Baseline – Results From a Randomized Controlled Trial
To test the hypothesis that sumatriptan iontophoretic transdermal system (TDS) is associated with lower rates of treatment‐emergent nausea (TEN) relative to placebo, as well as to compare the…
Sumatriptan: a review of its pharmacokinetics, pharmacodynamics and efficacy in the acute treatment of migraine
TLDR
This evaluation specifically reviews the pharmacokinetics, pharmacodynamics, clinical efficacy, and safety of different formulations and dosages of sumatriptan used for the acute treatment of migraines.
Sumatriptan Transdermal System Can Be Correctly Assembled and Applied During Migraine Attacks
The objective of this study was to validate the ease of assembly and application of the sumatriptan iontophoretic transdermal system (sumatriptan TDS, Zecuity®, NuPathe, Inc., Malvern, PA, USA)…
A Sumatriptan Iontophoretic Transdermal System for the Acute Treatment of Migraine
TLDR
The sumatriptan iontophoretic transdermal system uses proprietary technology to circumvent the gastrointestinal tract while delivering triptan therapy for the acute treatment of migraine.
Sumatriptan succinate: pharmacokinetics of different formulations in clinical practice
TLDR
The new drug formulations that are the most similar to the pharmacokinetics parameters of the subcutaneous sumatriptan are promising because they both improve pharmacokinetic bioavailability bypassing the first-pass metabolism and increase patient compliance.
Sumatriptan iontophoretic transdermal system for the acute treatment of migraine.
TLDR
This sumatriptan transdermal system may be a good choice for migraineurs with severe nausea or vomiting, those with intolerable triptan-related adverse events and/or those not responding optimally to oral medications.
...
...

References

SHOWING 1-10 OF 19 REFERENCES
Bioequivalence and Rapid Absorption of Zolmitriptan Nasal Spray Compared with Oral Tablets in Healthy Japanese Subjects
TLDR
The rapid absorption of zolmitriptan nasal spray may explain the faster relief from migraine reported in patients compared with oral zolMITriptan.
Multimechanistic (sumatriptan-naproxen) early intervention for the acute treatment of migraine
TLDR
The fixed-dose single-tablet formulation of sumatriptan/naproxen was effective and well tolerated in an early intervention paradigm for the acute treatment of migraine, including traditional and nontraditional symptoms.
Gastric Stasis in Migraine: More Than Just a Paroxysmal Abnormality During a Migraine Attack
TLDR
The aim of this article is to evaluate gastric motility and emptying in the ictal and interictal period in migraine.
5-HT1-like receptors: a time to bid goodbye.
Effects of sensitization of trigeminovascular neurons to triptan therapy during migraine.
Migraine Symptoms: Results of a Survey of Self‐Reported Migraineurs
TLDR
The most common reported symptoms associated with migraine were pain, nausea, problems with vision, and vomiting, and the most important features of a migraine medication were rapid and effective relief of headache pain, decreasing the likelihood of headache recurrence, and not causing nausea.
Sensitization of meningeal sensory neurons and the origin of headaches
TLDR
The activity of primary afferent neurons in the rat trigeminal ganglion that innervate the dural venous sinuses are recorded, showing properties of meningeal afferents that may contribute to the intracranial mechanical hypersensitivity that is characteristic of some types of clinically occurring headaches, and to the throbbing pain of migraine.
The International Classification of Headache Disorders
TLDR
The ICHD identifies and categorizes more than a hundred different kinds of headache in a logical, hierarchal system and has provided explicit diagnostic criteria for all of the headache disorders listed.
Triptans, 5-HT1B/1D receptor agonists in the acute treatment of migraine
  • 2006
A Unique Iontophoretic Patch for Optimal Transdermal Delivery of Sumatriptan
TLDR
This study met the initial objective to define the dose–current relationship in humans as well as delimiting specific current and current density targets for a well tolerated patch design that can deliver therapeutic drug levels for longer periods than currently possible.
...
...