Zelrix™: A Novel Transdermal Formulation of Sumatriptan

@article{Pierce2009ZelrixAN,
  title={Zelrix{\texttrademark}: A Novel Transdermal Formulation of Sumatriptan},
  author={Mark W. Pierce and Thomas C. Marbury and Carol O'neill and Steven J. Siegel and Wei Du and Terri B. Sebree},
  journal={Headache: The Journal of Head and Face Pain},
  year={2009},
  volume={49}
}
Objective.— This study evaluated the pharmacokinetic and tolerability profiles of Zelrix™ (NuPathe Inc., Conshohocken, PA, USA), the novel formulation of sumatriptan (formerly known as NP101). 
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Evaluation of the efficacy and safety of transdermal sumatriptan in migraine patients who have baseline nausea in patients with baseline nausea finds it to be safe and effective.
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The new drug formulations that are the most similar to the pharmacokinetics parameters of the subcutaneous sumatriptan are promising because they both improve pharmacokinetic bioavailability bypassing the first-pass metabolism and increase patient compliance.
Sumatriptan iontophoretic transdermal system for the acute treatment of migraine.
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This sumatriptan transdermal system may be a good choice for migraineurs with severe nausea or vomiting, those with intolerable triptan-related adverse events and/or those not responding optimally to oral medications.
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