Zelda overcomes the high intrinsic nucleosome barrier at enhancers during Drosophila zygotic genome activation.

@article{Sun2015ZeldaOT,
  title={Zelda overcomes the high intrinsic nucleosome barrier at enhancers during Drosophila zygotic genome activation.},
  author={Yujia Sun and C. Y. Nien and Kai Chen and Hsiao-Yun Liu and Jeff Johnston and Julia Zeitlinger and Christine A. Rushlow},
  journal={Genome research},
  year={2015},
  volume={25 11},
  pages={
          1703-14
        }
}
The Drosophila genome activator Vielfaltig (Vfl), also known as Zelda (Zld), is thought to prime enhancers for activation by patterning transcription factors (TFs). Such priming is accompanied by increased chromatin accessibility, but the mechanisms by which this occurs are poorly understood. Here, we analyze the effect of Zld on genome-wide nucleosome occupancy and binding of the patterning TF Dorsal (Dl). Our results show that early enhancers are characterized by an intrinsically high… CONTINUE READING
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