Zein-Based Nanoparticles Improve the Oral Bioavailability of Resveratrol and Its Anti-inflammatory Effects in a Mouse Model of Endotoxic Shock.

@article{Pealva2015ZeinBasedNI,
  title={Zein-Based Nanoparticles Improve the Oral Bioavailability of Resveratrol and Its Anti-inflammatory Effects in a Mouse Model of Endotoxic Shock.},
  author={Rebeca Pe{\~n}alva and Irene Esparza and Eneko Larra{\~n}eta and Carlos J Gonz{\'a}lez-Navarro and Carlos Gamazo and Juan M Irache},
  journal={Journal of agricultural and food chemistry},
  year={2015},
  volume={63 23},
  pages={5603-11}
}
Resveratrol offers pleiotropic health benefits including a reported ability to inhibit lipopolysaccharide (LPS)-induced cytokine production. The aim of this work was to prepare, characterize, and evaluate a resveratrol nanoparticulate formulation based on zein. For this purpose, the oral bioavailability of the encapsulated polyphenol as well as its anti-inflammatory effects in a mouse model of endotoxic shock was studied. The resveratrol-loaded nanoparticles displayed a mean size of 307 ± 3 nm… CONTINUE READING
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