Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation.

  title={Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation.},
  author={Jiyuan Chen and Mark C Fishman},
  volume={122 12},
The fashioning of a vertebrate organ requires integration of decisions of cell fate by individual cells with those that regulate organotypic form. Logical candidates for this role, in an organ such as the heart, are genes that initiate the differentiation process leading to heart muscle and those that define the earliest embryonic heart field, but for neither class are genes defined. We cloned zebrafish Nkx2.5, a homolog of the tinman homeodomain gene needed for visceral and cardiac mesoderm… CONTINUE READING
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