Zebrafish smoothened functions in ventral neural tube specification and axon tract formation.

@article{Varga2001ZebrafishSF,
  title={Zebrafish smoothened functions in ventral neural tube specification and axon tract formation.},
  author={Zolt{\'a}n M. Varga and Angel Amores and Katharine E Lewis and Y. L. Yan and John H Postlethwait and Judith S Eisen and Monte Westerfield},
  journal={Development},
  year={2001},
  volume={128 18},
  pages={3497-509}
}
Sonic hedgehog (Shh) signaling patterns many vertebrate tissues. shh mutations dramatically affect mouse ventral forebrain and floor plate but produce minor defects in zebrafish. Zebrafish have two mammalian Shh orthologs, sonic hedgehog and tiggy-winkle hedgehog, and another gene, echidna hedgehog, that could have overlapping functions. To examine the role of Hedgehog signaling in zebrafish, we have characterized slow muscle omitted (smu) mutants. We show that smu encodes a zebrafish ortholog… CONTINUE READING
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